Can Helicobacter pylori Eradication Treatment Modify the Metabolic Response to Bariatric Surgery?
| Autor: | Juana A Flores Le-Roux, Alberto Goday, Anna Busquets Pou, Luis Barranco Priego, Olga Castañer, José M. Ramón, Maria Del Mar Iglesias, D. Benaiges |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Sleeve gastrectomy Endocrinology Diabetes and Metabolism medicine.medical_treatment Biopsy Gastric Bypass Bariatric Surgery Helicobacter Infections 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Weight loss Gastrectomy Clarithromycin Gastroscopy Weight Loss medicine Humans Prospective Studies Prospective cohort study Omeprazole Retrospective Studies Nutrition and Dietetics biology Triglyceride Helicobacter pylori business.industry Stomach Amoxicillin Middle Aged biology.organism_classification Surgery Anti-Bacterial Agents Obesity Morbid chemistry 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Female medicine.symptom business medicine.drug |
| Zdroj: | Obesity surgery. 28(8) |
| ISSN: | 1708-0428 |
| Popis: | Helicobacter pylori (HP) colonization is common in severely obese patients undergoing bariatric surgery. HP eradication treatment could influence the evolution of weight loss and metabolic markers after bariatric surgery. To assess the influence of HP eradication in the clinical course of morbid obesity patients treated with bariatric surgery (gastric bypass (LRYGB) and sleeve gastrectomy (LSG)) Retrospective analysis of a prospective cohort of 229 patients that underwent bariatric surgery between 2010 and 2013 in Hospital del Mar. HP infection was tested preoperatively by gastric biopsy and, if positive, treated with omeprazole, clarithromycin, and amoxicillin for 14 days. Patients were followed at 3, 6, 12, 18, and 24 months after bariatric surgery. Short-term weight loss and metabolic outcomes were evaluated. HP treated (HPt) patients had a greater reduction in BMI at 3 months after LSG (ΔBMI (kg/cm2) 8.5 ± 4.1 vs 11.3 ± 3.05 kg/m2; p = 0.004) and a reduction in the evolution of triglyceride levels from baseline to 12 months (p = 0.014) compared to HP-negative (HP−) subjects. Also, non-diabetic HPt patients had a greater reduction in glucose levels at all time points that was maintained up to 24 months after LRYGB (p = 0.003). No differences were observed in total and LDL cholesterol levels, HOMA-IR, or HbA1C. Preoperative HP eradication has a short-term influence on some metabolic parameters after bariatric surgery. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink