Differentiation of Type 1 ILCs from a Common Progenitor to All Helper-like Innate Lymphoid Cell Lineages
| Autor: | Thomas Hoyler, Dietmar Pfeifer, Leif Rogell, Yakup Tanriver, Sebastian J. Arnold, Rita G. Domingues, Diogo Fonseca-Pereira, Karolina Ebert, Luisa Möhle, Henrique Veiga-Fernandes, Meinrad Busslinger, Carola Fabiunke, Ildiko Rita Dunay, Melanie Flach, Andreas Diefenbach, Veronika Sexl, Christoph S.N. Klose |
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| Jazyk: | angličtina |
| Předmět: |
Cellular differentiation
Lineage (evolution) Bone Marrow Cells GATA3 Transcription Factor Biology General Biochemistry Genetics and Molecular Biology Mice medicine Animals Lymphocytes skin and connective tissue diseases Progenitor Inhibitor of Differentiation Protein 2 Receptors Interleukin-7 Biochemistry Genetics and Molecular Biology(all) Intracellular parasite Stem Cells Innate lymphoid cell NFIL3 Cell Differentiation T helper cell Immunity Innate Mice Inbred C57BL body regions medicine.anatomical_structure Immunology Toxoplasma Intracellular Toxoplasmosis |
| Zdroj: | Cell |
| ISSN: | 0092-8674 |
| DOI: | 10.1016/j.cell.2014.03.030 |
| Popis: | SummaryInnate lymphoid cells (ILCs) are a recently recognized group of lymphocytes that have important functions in protecting epithelial barriers against infections and in maintaining organ homeostasis. ILCs have been categorized into three distinct groups, transcriptional circuitry and effector functions of which strikingly resemble the various T helper cell subsets. Here, we identify a common, Id2-expressing progenitor to all interleukin 7 receptor-expressing, “helper-like” ILC lineages, the CHILP. Interestingly, the CHILP differentiated into ILC2 and ILC3 lineages, but not into conventional natural killer (cNK) cells that have been considered an ILC1 subset. Instead, the CHILP gave rise to a peculiar NKp46+ IL-7Rα+ ILC lineage that required T-bet for specification and was distinct of cNK cells or other ILC lineages. Such ILC1s coproduced high levels of IFN-γ and TNF and protected against infections with the intracellular parasite Toxoplasma gondii. Our data significantly advance our understanding of ILC differentiation and presents evidence for a new ILC lineage that protects barrier surfaces against intracellular infections. |
| Databáze: | OpenAIRE |
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