Placenta: a possible predictor of vitamin A deficiency
| Autor: | Andréa Ramalho, Cláudia Saunders, Mirian Martins Gomes |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
medicine.medical_specialty Placenta Serum retinol Medicine (miscellaneous) Sensitivity and Specificity Umbilical cord Young Adult chemistry.chemical_compound Pregnancy Internal medicine medicine Humans Vitamin A Carotenoid chemistry.chemical_classification Nutrition and Dietetics Receiver operating characteristic Vitamin A Deficiency business.industry Infant Newborn Retinol Curve analysis medicine.disease Vitamin A deficiency medicine.anatomical_structure Endocrinology chemistry Female business Brazil |
| Zdroj: | British Journal of Nutrition. 103:1340-1344 |
| ISSN: | 1475-2662 0007-1145 |
| Popis: | The objective of the present study is to assess the association between vitamin A deficiency (VAD) evaluated by serum retinol concentration from the mother and umbilical cord and placental concentration of retinol and carotenoids to propose placental values representative of deficiency. Two hundred and sixty-two puerperal women and their newborns were assessed. Concentration of serum and placental retinol and carotenoids was determined by the spectrophotometric method. Receiver operating characteristic (ROC) curve analysis was performed according to two cut-off points (0·70 and 1·05 μmol/l) to represent deficiency in the placental concentration. No difference between averages of placental retinol and carotenoids was observed in the puerperal women regardless of the cut-off point used to define VAD. In relation to the newborns, a decrease (P = 0·012) in placental retinol averages in individuals with VAD was observed when the 1·05 μmol/l cut-off point was adopted. In respect to the placental carotenoid averages, a decrease is observed for both the cut-off points (P = 0·013 and 0·019 for 1·05 and 0·7 μmol/l, respectively). The ROC curve results point to the value of 0·80 μmol/l as representing deficiency with greater values found for sensitivity (66·7 %), specificity (41·7 %) and accuracy (65 %) when the 0·70 μmol/l cut-off point was adopted. The results of the present study show an association between the placental concentration of retinol and carotenoids with clinical VAD, suggesting the need for further studies on more severe cases of deficiency. |
| Databáze: | OpenAIRE |
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