Cerebral White-Matter Hypoplasia
| Autor: | Edward P. Richardson, Amrik S. Chattha |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent Inflammation Ventricular system Cerebral palsy Arts and Humanities (miscellaneous) Intellectual Disability medicine Humans Child Intellectual impairment Cerebral white matter Cerebral Palsy Brain Infant Organ Size medicine.disease Hypoplasia Gliosis Child Preschool Cerebral white matter hypoplasia Female Neurology (clinical) medicine.symptom Psychology Neuroscience |
| Zdroj: | Archives of Neurology. 34:137-141 |
| ISSN: | 0003-9942 |
| DOI: | 10.1001/archneur.1977.00500150023003 |
| Popis: | • Twelve patients, including three sisters, with lifelong severe intellectual impairment and neurologic defects were found to have generalized hypoplasia of the cerebral white matter, with corresponding enlargement of the ventricular system. Gray-matter structures were remarkably intact. Reactive cellular changes (gliosis, phagocytosis, inflammation) were absent. To our knowledge, this particular syndrome has not previously been delineated in the extensive literature on cerebral palsy. The abnormalities in these cases could result from the effects of a selectively acting tissuedamaging factor, such as has been postulated in perinatal telencephalic leukoencephalopathy, but the factors underlying the disorder are still unknown. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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