Caulobacter crescentus intrinsic dimorphism provides a prompt bimodal response to copper stress
| Autor: | Sébastien Gillet, Françoise Tilquin, Jean-Yves Matroule, Emeline Lawarée, Pierre Cambier, Sophie Le Blastier, Gwennaëlle Louis |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Microbiology (medical) 030106 microbiology Immunology Population Context (language use) Applied Microbiology and Biotechnology Microbiology 03 medical and health sciences Stress Physiological Caulobacter crescentus Genetics medicine Homeostasis education education.field_of_study biology Negative chemotaxis Ecology Chemotaxis Asymmetric Cell Division Copper toxicity Cell Biology biology.organism_classification medicine.disease Phenotype Cell biology 030104 developmental biology Reprogramming Copper |
| Zdroj: | Nature Microbiology. 1(9) |
| ISSN: | 2058-5276 |
| Popis: | Stress response to fluctuating environments often implies a time-consuming reprogramming of gene expression. In bacteria, the so-called bet hedging strategy, which promotes phenotypic stochasticity within a cell population, is the only fast stress response described so far1. Here, we show that Caulobacter crescentus asymmetrical cell division allows an immediate bimodal response to a toxic metals-rich environment by allocating specific defence strategies to morphologically and functionally distinct siblings. In this context, a motile swarmer cell favours negative chemotaxis to flee from a copper source, whereas a sessile stalked sibling engages a ready-to-use PcoAB copper homeostasis system, providing evidence of a prompt stress response through intrinsic bacterial dimorphism. Depending on its dimorphic life cycle, Caulobacter crescentus differentially initiates an efflux or chemotactic response to avoid copper toxicity. |
| Databáze: | OpenAIRE |
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