Biomedical approach in autism spectrum disorders—the importance of assessing inflammation
| Autor: | Dario Siniscalco, Eugene Bosmans, Kenny L. De Meirleir, Tatjana Mijatovic, Vincent C. Lombardi, K.A. Subramanian |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
autism Inflammation Immune Dysfunction behavioral disciplines and activities 03 medical and health sciences Nonverbal communication immune dysfunction 0302 clinical medicine mental disorders medicine Personalized therapy lcsh:Science (General) business.industry biomedical evaluation intestinal dysfunctions medicine.disease Social relation 030104 developmental biology inflammation Autism Communication skills medicine.symptom business 030217 neurology & neurosurgery Clinical psychology lcsh:Q1-390 |
| Zdroj: | AIMS Molecular Science, Vol 5, Iss 3, Pp 173-182 (2018) |
| ISSN: | 2372-0301 |
| Popis: | Autism spectrum disorders (ASD) are severe heterogeneous neurodevelopmental disorders characterized by dysfunctions in social interaction and communication skills, repetitive and stereotypic verbal and nonverbal behaviors. Published findings have identified widespread changes in the immune systems of children with autism, at the systemic and cellular levels, suggesting that autism may, in fact, be a systemic disorder with connections to abnormal immune responses. Evaluating autism is hindered by a lack of specific biomarkers, making these pathologies difficult to diagnose. A critical priority for the future of ASD management is the identification of potential targets for the development of diagnostic and therapeutic strategies. The purpose of this brief report is to raise awareness regarding the involvement of different inflammatory processes in ASD and the need to assess them as a part of a biomedical evaluation. An extensive analysis of biomarkers relating to inflammation, immune dysfunctions, intestinal dysfunctions and infections will assist in the management of the autistic patient through a more personalized therapy. |
| Databáze: | OpenAIRE |
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