Association Between Male Sex and Outcomes of Coronavirus Disease 2019 (COVID-19)—A Danish Nationwide, Register-based Study
| Autor: | Lars Køber, Matthew Phelps, Gunnar Gislason, Mikkel Porsborg Andersen, Kristian Kragholm, Jawad H. Butt, Charlotte Andersson, Christoffer Polcwiartek, Thomas A. Gerds, Emil L. Fosbøl, Christian Torp-Pedersen, Morten Schou, Lauge Østergaard |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Microbiology (medical) medicine.medical_specialty Octogenarians Denmark severity Comorbidity outcomes 03 medical and health sciences 0302 clinical medicine COVID-19 Testing Risk Factors Diabetes mellitus Internal medicine Major Article Medicine Humans 030212 general & internal medicine Myocardial infarction Stroke Aged 80 and over business.industry SARS-CoV-2 Absolute risk reduction COVID-19 Atrial fibrillation Middle Aged medicine.disease Denmark/epidemiology AcademicSubjects/MED00290 Infectious Diseases Heart failure Sex Female business 030217 neurology & neurosurgery Kidney disease Follow-Up Studies |
| Zdroj: | Clinical Infectious Diseases Kragholm, K, Andersen, M P, Gerds, T A, Butt, J H, Østergaard, L, Polcwiartek, C, Phelps, M, Andersson, C, Gislason, G H, Torp-Pedersen, C, Køber, L, Schou, M & Fosbøl, E L 2021, ' Association between male sex and outcomes of Coronavirus Disease 2019 (Covid-19)-a Danish nationwide, register-based study ', Clinical Infectious Diseases, vol. 73, no. 11, pp. e4025–e4030 . https://doi.org/10.1093/cid/ciaa924 Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America |
| ISSN: | 1537-6591 1058-4838 |
| DOI: | 10.1093/cid/ciaa924 |
| Popis: | Background and Objectives Male sex has been associated with severe coronavirus disease 2019 (COVID-19) infection. We examined the association between male sex and severe COVID-19 infection and if an increased risk remains after adjustment for age and comorbidities. Methods Nationwide register-based follow-up study of COVID-19 patients in Denmark until 16 May 2020. Average risk ratio comparing 30-day composite outcome of all-cause death, severe COVID-19 diagnosis or intensive care unit (ICU) admission for men versus women standardized to the age and comorbidity distribution of all patients were derived from multivariable Cox regression. Included covariates were age, hypertension, diagnoses including obesity, alcohol, sleep apnea, diabetes, chronic obstructive pulmonary disease, previous myocardial infarction (MI), ischemic heart disease (IHD), heart failure (HF), atrial fibrillation (AF), stroke, peripheral artery disease, cancer, liver, rheumatic, and chronic kidney disease (CKD). Results Of 4842 COVID-19 patients, 2281 (47.1%) were men. Median age was 57 [25%–75% 43–73] for men versus 52 [38–71] for women (P < .001); however, octogenarians had equal sex distribution. Alcohol diagnosis, diabetes, hypertension, sleep apnea, prior MI and IHD (all P < .001) as well as AF, stroke, and HF (all P = .01) were more often seen in men, and so was CKD (P = .03). Obesity diagnosis (P < .001) were more often seen in women. Other comorbidity differences were insignificant (P > .05). The fully adjusted average risk ratio was 1.63 [95% CI, 1.44–1.84]. Conclusions Men with COVID-19 infection have >50% higher risk of all-cause death, severe COVID-19 infection, or ICU admission than women. The excess risk was not explained by age and comorbidities. |
| Databáze: | OpenAIRE |
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