Image-Guided Robotic Stereotactic Body Radiation Therapy for Liver Metastases: Is There a Dose Response Relationship?
| Autor: | Eric Lartigau, Thomas Lacornerie, Antoine Adenis, Nicolas Penel, Claire Vautravers-Dewas, Sylvain Dewas, Xavier Mirabel, F. Bonodeau |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Stereotactic body radiation therapy Nausea Colorectal cancer medicine.medical_treatment Radiosurgery Young Adult Fiducial Markers medicine Humans Radiology Nuclear Medicine and imaging Adverse effect Aged Retrospective Studies Aged 80 and over Radiation business.industry Respiration Liver Neoplasms Remission Induction Cancer Dose-Response Relationship Radiation Robotics Middle Aged medicine.disease Tumor Burden Surgery Radiography Radiation therapy Dose–response relationship Treatment Outcome Surgery Computer-Assisted Oncology Toxicity Disease Progression Feasibility Studies Female Dose Fractionation Radiation France medicine.symptom business Follow-Up Studies |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 81:e39-e47 |
| ISSN: | 0360-3016 |
| Popis: | Purpose To evaluate the outcome, tolerance, and toxicity of stereotactic body radiotherapy, using image-guided robotic radiation delivery, for the treatment of patients with unresectable liver metastases. Methods and Material Patients were treated with real-time respiratory tracking between July 2007 and April 2009. Their records were retrospectively reviewed. Metastases from colorectal carcinoma and other primaries were not necessarily confined to liver. Toxicity was evaluated using National Cancer Institute Common Criteria for Adverse Events version 3.0. Results Forty-two patients with 62 metastases were treated with two dose levels of 40 Gy in four Dose per Fraction (23) and 45 Gy in three Dose per Fraction (13). Median follow-up was 14.3 months (range, 3–23 months). Actuarial local control for 1 and 2 years was 90% and 86%, respectively. At last follow-up, 41 (66%) complete responses and eight (13%) partial responses were observed. Five lesions were stable. Nine lesions (13%) were locally progressed. Overall survival was 94% at 1 year and 48% at 2 years. The most common toxicity was Grade 1 or 2 nausea. One patient experienced Grade 3 epidermitis. The dose level did not significantly contribute to the outcome, toxicity, or survival. Conclusion Image-guided robotic stereotactic body radiation therapy is feasible, safe, and effective, with encouraging local control. It provides a strong alternative for patients who cannot undergo surgery. |
| Databáze: | OpenAIRE |
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