Comparison of five bifunctional chelate techniques for 90Y-labeled monoclonal antibody CO17-1A
| Autor: | J. B. Stubbs, O. A. Gansow, Zenon Steplewski, Michael G. Stabin, Lee C. Washburn, E. C. Holloway, Yu-Chen C. Lee, Billy L. Byrd, Tan Tan Sun, Martin W. Brechbiel, J.E. Crook |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
medicine.drug_class
Stereochemistry animal diseases Transplantation Heterologous Radioimmunoassay Heterologous Mice Nude Conjugated system Monoclonal antibody Mice Bifunctional chelate medicine Animals Humans Tissue Distribution Yttrium Radioisotopes Chelating Agents biology Chemistry organic chemicals Antibodies Monoclonal General Medicine Monoclonal Antibody CO17-1A Neoplasms Experimental respiratory system Molecular biology Transplantation Isotope Labeling cardiovascular system biology.protein Female Indicators and Reagents Antibody Neoplasm Transplantation circulatory and respiratory physiology |
| Zdroj: | International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology. 18(3) |
| ISSN: | 0883-2897 |
| Popis: | Monoclonal antibody CO17-1A was radiolabeled with 90Y by five bifunctional chelate techniques. Radiation absorbed dose estimates for normal organs and tumor were calculated for each preparation based on timed tissue distribution studies in nude mice bearing SW 948 human colorectal carcinoma xenografts. The cyclic DTPA anhydride technique was inferior to the four other techniques studied. Data for SCN-Bz-DTPA and SCN-Bz-Mx-DTPA, which were conjugated to epsilon-lysyl amino groups, were similar to those for NH2-Bz-DTPA and NH2-Bz-Mx-DTPA, which were conjugated site specifically to oligosaccharides. |
| Databáze: | OpenAIRE |
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