The Possible Role of the Angiotensin System in the Pathophysiology of Schizophrenia: Implications for Pharmacotherapy
| Autor: | SeungJu Jackie Oh, Xiaoduo Fan |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Bioinformatics
Renin-Angiotensin System 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Dopamine medicine Humans Pharmacology (medical) Telmisartan Neurotransmitter Neurotransmitter Agents Mechanism (biology) business.industry Glutamate receptor medicine.disease 030227 psychiatry Psychiatry and Mental health medicine.anatomical_structure chemistry Dopaminergic pathways Schizophrenia Cytokines Neurology (clinical) Psychopharmacology business Angiotensin II Type 1 Receptor Blockers 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | CNS drugs. 33(6) |
| ISSN: | 1179-1934 |
| Popis: | A growing body of literature has elucidated the involvement of the central renin–angiotensin system (RAS) in various neuropsychiatric diseases. While consensus on the exact mechanism of the central RAS in schizophrenia pathophysiology does not currently exist, increasing evidence reveals promise in harnessing the therapeutic potential of RAS modulation in the treatment of schizophrenia. In this review, we examine how the central RAS affects inflammation, glutamate, dopamine, gamma-aminobutyric acid (GABA), and peroxisome proliferator-activated receptor (PPAR)-γ, all of which are associated with schizophrenia etiology. In addition, a recent study has demonstrated the therapeutic potential of RAS modulators, especially angiotensin II type 1 receptor blockers (ARBs), as adjunctive therapy to the currently available antipsychotic medications for schizophrenia treatment. With a greater understanding of how RAS inhibition directly modulates neurotransmitter balance in the brain, it is possible that compounds with RAS-inhibiting properties could be used to optimize physiological levels of glutamate, dopamine, and GABA, and the balance among the three neurotransmitters, analogously to how antipsychotic medications mediate the dopaminergic pathways. It can be hoped that a novel approach based on this concept, such as adjunctive telmisartan therapy, may offer practical interventional strategies to address currently unmet therapeutic needs in patients with schizophrenia, especially those with treatment-resistant schizophrenia. |
| Databáze: | OpenAIRE |
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