Inflammatory response of coronary artery disease postmenopausal women is associated with the IVS1-397T > C estrogen receptor α polymorphism
| Autor: | Aleksandra Rutkowska, Janusz Siebert, Jolanta Myśliwska, Krzysztof Szyndler, Łukasz Hak, Dominik Rachoń |
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| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
T-Lymphocytes CD14 Immunology Lipopolysaccharide Receptors Estrogen receptor Coronary Artery Disease Lymphocyte Activation Monocytes Angina Coronary artery disease Leukocyte Count Polymorphism (computer science) Internal medicine medicine Humans Immunology and Allergy Genetic Predisposition to Disease Coronary Artery Bypass Cells Cultured Aged Whole blood Polymorphism Genetic Interleukin-6 Tumor Necrosis Factor-alpha business.industry Receptors IgG Estrogen Receptor alpha Middle Aged Reference Standards medicine.disease Postmenopause medicine.anatomical_structure Endocrinology Female Tumor necrosis factor alpha business Artery |
| Zdroj: | Clinical Immunology. 130:355-364 |
| ISSN: | 1521-6616 |
| Popis: | We analyzed the relationship between the IVS1-397T > C polymorphism of estrogen receptor α gene and inflammatory response of eighty postmenopausal women with an established coronary artery disease (CAD). We found that the IVS1-397T allele carriers exhibited an enhanced inflammatory response in vivo and in vitro. These patients had a higher number of total monocytes and their CD14+CD16+ inflammatory subset in relation to CC homozygotes. The CT and TT women's LPS-stimulated whole blood cell cultures produced more IL6 and TNFα than did the cultures of CC women. Moreover, significantly more of the T allele patients had major post-coronary artery bypass grafting complications and less of them experienced subjective angina pectoris improvement. Summarizing, the IVS1-397T > C polymorphism allows us to identify a group of postmenopausal women with the strong inflammatory response which is associated with a higher incidence of the major post-CABG adverse cardiovascular complications. |
| Databáze: | OpenAIRE |
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