Atypical presentations of herpesvirus infections in patients with chronic lymphocytic leukemia
| Autor: | John McSorley, Justin M. Haught, Pooja Khera, Joseph C. English |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
Pathology medicine.medical_specialty Biopsy Chronic lymphocytic leukemia Physical examination Dermatology medicine.disease_cause Virus Herpesviridae Diagnosis Differential Alphaherpesvirinae Skin Ulcer Humans Medicine Aged biology medicine.diagnostic_test business.industry Erythematous papule Cancer Herpesviridae Infections biology.organism_classification medicine.disease Leukemia Lymphocytic Chronic B-Cell Female Differential diagnosis business |
| Zdroj: | Journal of the American Academy of Dermatology. 60:484-486 |
| ISSN: | 0190-9622 |
| DOI: | 10.1016/j.jaad.2008.08.047 |
| Popis: | The characteristic presentation of herpesvirus infections is a vesicular rash. The initial lesions appear as erythematous papules that turn into grouped vesicles and pustules eventuating into crusts. In most cases, the features are so characteristic that a diagnosis can be made by history and physical examination without further diagnostic testing. However, patients who are immunosuppressed (including those with hematologic malignancies) often have atypical presentations of herpesvirus infections. These cases require a high index of suspicion and appropriate diagnostic testing for proper management. In this report, we describe two patients with chronic lymphocytic leukemia who developed atypical presentations of herpes zoster and herpes simplex infections. Herpetic infections should always be in the differential diagnosis of cutaneous ulcerations with necrosis in patients who are immunocompromised. Because of the atypical appearance of the lesions, the diagnosis may be confused or mistaken for several other conditions. |
| Databáze: | OpenAIRE |
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