Relationship between maternal phthalate exposure and offspring size at birth
| Autor: | Zong Chen, Yangqian Jiang, Minmin Jiang, Aifen Zhou, Bin Zhang, Wenqian Huo, Yingshuang Zhu, Yang Peng, Yanjian Wan, Chuansha Wu, Hongxiu Liu, Shunqing Xu, Wei Xia, Yuanyuan Li |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty China Environmental Engineering Offspring Metabolite Urinary system Birth weight Phthalic Acids Urine 010501 environmental sciences 01 natural sciences 03 medical and health sciences chemistry.chemical_compound Sex Factors Pregnancy Internal medicine Environmental Chemistry Medicine Birth Weight Humans Waste Management and Disposal 0105 earth and related environmental sciences business.industry Phthalate Infant Newborn Pollution Confidence interval 030104 developmental biology Endocrinology chemistry Maternal Exposure Cohort Female business |
| Zdroj: | The Science of the total environment. 612 |
| ISSN: | 1879-1026 |
| Popis: | Research findings on effects of prenatal phthalate exposure on fetal growth were inconsistent. Increasing evidence from animal studies has indicated a potential sex-specific effect of phthalates on fetal growth, but the current human data was limited. In this study, we aimed to estimate the relationships between maternal phthalate exposure and infant birth size. Six major phthalate metabolite levels of urine samples were measured among pregnant women ( n = 1002) from the Healthy Baby Cohort (HBC), China. The associations between urinary phthalate metabolites levels and birth size (birth weight, birth length, birth weight z-scores and ponderal index) were estimated using linear regression models. In boys, the ln-transformed di-2-ethylhexyl phthalate (DEHP) metabolite levels were significantly associated with increased birth weight and birth weight z-scores. Additionally, each ln-unit increase in mono-(2-ethyl-5-carbox-ypentyl) phthalate (MECPP) was associated with a 0.25 kg/m 3 [95% confidence interval (CI): 0.03, 0.47] increase in ponderal index in boys. However, we did not observe any significant association of maternal phthalate metabolite levels with any of the outcomes in girls. Our data suggested potential sex-specific associations of maternal phthalate exposure with increased birth weight and ponderal index, which were merely apparent in boys. |
| Databáze: | OpenAIRE |
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