Prostate Cancer Stem Cells: Viewing Signaling Cascades at a Finer Resolution
| Autor: | Sobia Tabassum, Muhammad Zahid Qureshi, Muhammad Ismail, Mirna Azalea Romero, Ammad Ahmad Farooqi, Xiukun Lin |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Cellular differentiation Immunology Antineoplastic Agents Apoptosis Biology Mice 03 medical and health sciences 0302 clinical medicine Transforming Growth Factor beta Cancer stem cell microRNA Biomarkers Tumor Animals Humans Immunology and Allergy Hedgehog Proteins Induced stem cells Prostatic Neoplasms General Medicine Transforming growth factor beta Cell biology Wnt Proteins MicroRNAs Phenotype 030104 developmental biology 030220 oncology & carcinogenesis Neoplastic Stem Cells biology.protein Stem cell Signal transduction Neoplasm Transplantation Intracellular Signal Transduction |
| Zdroj: | Archivum Immunologiae et Therapiae Experimentalis. 64:217-223 |
| ISSN: | 1661-4917 0004-069X |
| DOI: | 10.1007/s00005-016-0383-0 |
| Popis: | It is becoming characteristically more understandable that within tumor cells, there lies a sub-population of tumor cells with "stem cell" like properties and remarkable ability of self-renewal. Many features of these self-renewing cells are comparable with normal stem cells and are termed as "cancer stem cells". Accumulating experimentally verified data has started to scratch the surface of spatio-temporally dysregulated intracellular signaling cascades in the biology of prostate cancer stem cells. We partition this multicomponent review into how different signaling cascades operate in cancer stem cells and how bioactive ingredients isolated from natural sources may modulate signaling network. |
| Databáze: | OpenAIRE |
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