Effect of eltenac in horses with induced endotoxaemia
| Autor: | C. A. Daniels, Robert J. MacKay, K. D. Gillis, H. F. Bleyaert, K. C. Thompson, A. M. Merritt, J. C. Johnson, J. E. Bailey, T. L. Katz |
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| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Respiratory rate Bacterial Toxins Thiophenes Plasma Random Allocation chemistry.chemical_compound Internal medicine White blood cell Blood plasma Heart rate Animals Medicine Horses Pulmonary Wedge Pressure Respiratory system Escherichia coli Infections Aniline Compounds Cross-Over Studies business.industry Respiration Anti-Inflammatory Agents Non-Steroidal General Medicine Blood proteins Endotoxemia Thromboxane B2 Endocrinology Blood pressure medicine.anatomical_structure chemistry Anesthesia Injections Intravenous Prostaglandins Horse Diseases business |
| Zdroj: | Equine Veterinary Journal. 32:26-31 |
| ISSN: | 2042-3306 0425-1644 |
| DOI: | 10.1111/j.2042-3306.2000.tb05330.x |
| Popis: | Summary Ten horses were used in a crossover study to evaluate the effectiveness of eltenac against endotoxaemia. Eltenac (0.5 mg/kg bwt) or saline control was given i.v. then 15 min later, intravenous infusion of endotoxin was begun and continued for 120 min (total dose 100 ng/kg bwt). Horses were monitored for heart and respiratory rates, pulmonary and carotid arterial pressure and core body temperature. Blood was sampled at intervals for measurement of haematological variables and plasma concentrations of lactate, prostanoid metabolites, tumour necrosis factor (TNF) and stress hormones. In comparison with saline-treatment, use of eltenac significantly protected against endotoxin-induced changes in respiratory rate, core temperature, systemic arterial blood pressure (SAP), pulmonary arterial pressure, PCV, and plasma protein, 6-keto prostaglandin F1α, thromboxane B2, epinephrine, and cortisol concentrations. Despite statistical effect of eltenac on SAP, values in both treatment groups remained well above baseline throughout the evaluation period. Significant protective effect of eltenac was not found for heart rate, white blood cell count, plasma lactate concentration or TNF activity. On the basis of these results, it is expected that use of eltenac will provide clinical benefit in horses with naturally occurring endotoxaemia. |
| Databáze: | OpenAIRE |
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