Assay dependence of long-term kinetics of SARS-CoV-2 antibodies
| Autor: | Dirk De Bruyne, Anneleen Schallier, Pedro Couck, Kenny Dauwe, Margaux Herpol, Sarah De Baets |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Time Factors Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses 030106 microbiology medicine.disease_cause Antibodies Viral Sensitivity and Specificity Serology COVID-19 Serological Testing 03 medical and health sciences 0302 clinical medicine medicine Humans 030212 general & internal medicine immunoassay skin and connective tissue diseases Coronavirus medicine.diagnostic_test biology long-term kinetics business.industry SARS-CoV-2 fungi Antibody titer Outbreak virus diseases COVID-19 General Medicine Virology body regions Titer Infectious Diseases Immunoassay Immunoglobulin G biology.protein Original Article Antibody business |
| Zdroj: | Diagnostic Microbiology and Infectious Disease |
| ISSN: | 1879-0070 |
| Popis: | Since the worldwide outbreak of the novel coronavirus (SARS-CoV-2), the question raised whether infected patients would elicit long-lasting protective immunity. Several companies developed serological assays for the detection of SARS-CoV-2 antibodies. In this study, we compared four different serology assays in convalescents up to seven months post-infection. Both Abbott assays showed a significative decrease of IgG antibodies over time. Whereas the Elecsys Anti‑SARS‑CoV‑2 N assay (Roche) initially showed a significant increase, antibody titers significantly decreased at the latest timepoint. Although not significant, the Elecsys Anti‑SARS‑CoV‑2 S assay (Roche) showed tendency towards increasing titers overtime. Our data showed that results of SARS-CoV-2 serology should be interpreted with caution. |
| Databáze: | OpenAIRE |
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