Age-related changes in regulator of G-protein signaling (RGS)-10 expression in peripheral and central immune cells may influence the risk for age-related degeneration
| Autor: | Kennie R. Shepherd, Jae-Kyung Lee, Jianjun Chang, Chenere P. Ramsey, Isadora Porter, Malú G. Tansey, Jaegwon Chung, Danielle Oliver, George T. Kannarkat |
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| Rok vydání: | 2015 |
| Předmět: |
CD4-Positive T-Lymphocytes
Male Risk Aging medicine.medical_specialty Tyrosine 3-Monooxygenase Neuroimmunomodulation medicine.medical_treatment Gene Expression Inflammation Biology Monocytes Article Immune system Internal medicine medicine Animals Humans Aging brain Cerebrospinal Fluid B-Lymphocytes Dopaminergic Neurons General Neuroscience Monocyte Dopaminergic Neurodegeneration Gene Expression Regulation Developmental medicine.disease Mice Inbred C57BL medicine.anatomical_structure Endocrinology Cytokine Nerve Degeneration Immunology Cytokines Female Microglia Neurology (clinical) Neuron Inflammation Mediators Geriatrics and Gerontology medicine.symptom RGS Proteins Developmental Biology |
| Zdroj: | Neurobiology of Aging. 36:1982-1993 |
| ISSN: | 0197-4580 |
| DOI: | 10.1016/j.neurobiolaging.2015.02.006 |
| Popis: | Inflammation in the aging brain increases risk for neurodegenerative disease. In humans, the Regulator of G-protein Signaling (RGS) 10 locus has been associated with age-related maculopathy. Chronic peripheral administration of lipopolysaccharide in the RGS10-null mice induces nigral dopaminergic (DA) degeneration, suggesting that RGS10 modulates neuroimmune interactions and may influence susceptibility to neurodegeneration. Since age is the strongest risk factor for neurodegenerative disease, we assessed whether RGS10 expression changes with age and whether aged RGS10-null mice have altered immune cell profiles. Loss of RGS10 in aged mice does not alter the regulation of nigral DA neurons but does alter B cell, monocyte, microglial and CD4+ T cell populations and inflammatory cytokine levels in the cerebrospinal fluid. These results suggest that loss of RGS10 is associated with an age-dependent dysregulation of peripheral and central immune cells rather than dysregulation of dopaminergic neuron function. |
| Databáze: | OpenAIRE |
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