Impaired Postnatal Development in C/EBP.BETA.-deficient Mice
| Autor: | Shizuo Akira, Naohiko Umesaki, Tao Bai, Tetsuji Tanaka, Makoto Matsumoto, Kazunori Yukawa |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Genotype Offspring Mutant Biology Mice chemistry.chemical_compound symbols.namesake Internal medicine medicine Animals Weaning Genotyping Fetus CCAAT-Enhancer-Binding Protein-beta Embryonic Stage Mice Mutant Strains Endocrinology chemistry Mendelian inheritance symbols Female Genes Lethal Animal Science and Zoology DNA |
| Zdroj: | Journal of Reproduction and Development. 52:645-649 |
| ISSN: | 1348-4400 0916-8818 |
| Popis: | Tail DNA genotyping of fetal and neonatal mice from C/EBPbeta heterozygous parents was performed to determine whether the decreased number of surviving C/EBPbeta mutants was caused by prenatal or postnatal death. Eighty-four 3-week-old mice born of heterozygous parents had significantly lower numbers of C/EBPbeta-deficient offspring than the expected Mendelian ratio (29.8%+/+, 65.5%+/-, 4.76%-/-, P0.05). The genotypes of 72 fetal mice from intercrossed heterozygotes showed approximately the expected 1:2:1 Mendelian ratio (18.1% +/+, 52.8% +/-, 29.2% -/-, P0.05). No difference in the proportions by sex could be detected in these perinates. This data indicates that C/EBPbeta-deficient mice have unknown lethal problems between the embryonic stage and weaning. |
| Databáze: | OpenAIRE |
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