C-reactive protein gene rs1205 polymorphism is associated with low-grade chronic inflammation in postmenopausal women

Autor: Iriane Prado de Santis, Juliana Dal-Ri Lindenau, Gislaine Krolow Casanova, Poli Mara Spritzer, Thaís Rasia da Silva, Ramon Bossardi Ramos, Karen Oppermann
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Women's Midlife Health, Vol 6, Iss 1, Pp 1-10 (2020)
Repositório Institucional da UFRGS
Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
Women's Midlife Health
ISSN: 2054-2690
DOI: 10.1186/s40695-020-00051-2
Popis: Background Cardiovascular disease is the leading cause of death in postmenopausal women, and inflammation is a key mechanism involved in the pathogenesis of atherosclerosis. High-sensitivity C-reactive protein (hs-CRP) has been used as a biomarker of inflammation. Considering that CRP gene rs1205 polymorphism has been associated with hs-CRP circulating levels, we evaluated whether rs1205 genotypes influence the presence of low-grade chronic inflammation, acting as a marker of cardiovascular risk. Methods We performed a cross-sectional study with biobanked blood samples from 327 postmenopausal women with no evidence of clinical disease. Genotyping for rs1205 C > T SNP of the CRP gene was done by real-time polymerase chain reaction with allelic discrimination assays. Results Mean age was 55.6 ± 5.6 years. Mean body mass index (BMI) was 27.3 ± 4.7. Participants were divided according to hs-CRP levels: ≥3 mg/l (low-grade chronic inflammation) or p = 0.018) and waist circumference ≥ 88 cm (PR 2.45; 95%CI 1.66–3.60; p Conclusions CRP rs1205 CC homozygotes may be at higher risk of a low-grade chronic inflammatory status compared to individuals carrying the T allele.
Databáze: OpenAIRE
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