A plasminogen-like protein, present in the apical extracellular environment of thyroid epithelial cells, degrades thyroglobulin in vitro
| Autor: | Pierre-Jean Lejeune, Jocelyne Barbaria, Bernard Mallet, Julie Dicristofaro, Catherine De Micco, Annie Giraud |
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| Rok vydání: | 2005 |
| Předmět: |
endocrine system
medicine.medical_specialty endocrine system diseases Swine medicine.medical_treatment Biophysics Thyroid Gland Biology Biochemistry Thyroglobulin Internal medicine Follicular phase Follicular lumen medicine Extracellular Animals Humans Protein Isoforms Secretion Molecular Biology Cells Cultured Thyroid Epithelial Cells Thyroid Cell Membrane Epithelial Cells Extracellular Fluid Plasminogen Cell Biology Cell biology Endocrinology medicine.anatomical_structure Hormone |
| Zdroj: | Biochemical and biophysical research communications. 338(2) |
| ISSN: | 0006-291X |
| Popis: | The prothyroid hormone, thyroglobulin (Tg), is stored at high concentrations in the thyroid follicular lumen as a soluble 19S homo-dimer and as heavier soluble (27S and 37S) and insoluble (Tgm) forms. Follicular degradation of Tg may contribute to maintaining Tg concentrations compatible with follicle integrity. Here, we report on the presence of a plasminogen-like protein in the follicular lumen of normal human thyroids and its synthesis and apical secretion by cultured epithelial thyroid cells. Since all the main luminal forms of Tg are cleaved by this plasminogen-like protein, we suggest that it contributes to Tg degradation in the follicular lumen. |
| Databáze: | OpenAIRE |
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