Synthesis and anti-barnacle activities of novel 3-isocyanotheonellin analogues
| Autor: | Yasuyuki Nogata, Masahiro Tada, Kazuhiro Chiba, Atsuko Yokoyama, Isamu Sakaguchi, Yoshikazu Kitano, Kyouji Shinshima, Erina Yoshimura |
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| Rok vydání: | 2003 |
| Předmět: |
Cyanides
Natural product Ecology Stereochemistry Thoracica Biological activity Aquatic Science Biology biology.organism_classification Applied Microbiology and Biotechnology Chemical synthesis Balanus Biofouling Inhibitory Concentration 50 chemistry.chemical_compound chemistry Cyclohexanes Barnacle (slang) Larva Toxicity Animals Sesquiterpenes Water Science and Technology EC50 |
| Zdroj: | Biofouling. 19:187-192 |
| ISSN: | 1029-2454 0892-7014 |
| DOI: | 10.1080/0892701021000053390 |
| Popis: | An antifouling active natural compound, 3-isocyanotheonellin, and its analogues were synthesized and evaluated for antifouling activity against the larvae of the barnacle Balanus amphirite in order to explore structure-activity relationships. The anti-barnacle effect of the 3-isocyanotheonellin analogues was in the EC50 range 0.18-7.20 micrograms ml-1. Some synthesized analogues exhibited potent antifouling activity as high as 3-isocyanothoenllin, and none of the synthesized isocyano compounds showed significant toxicity. The results of the present study suggest that an isocyano group and a hydrophobic site at a suitable position are important for potent antifouling activity without toxicity. |
| Databáze: | OpenAIRE |
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