MAGE-A family is involved in gastric cancer progression and indicates poor prognosis of gastric cancer patients
| Autor: | Fei Liu, Yanyun Wu, Weina Huang, Shina Liu, Baoen Shan, Danjing Yin, Lina Gu, Yishui Lian, Meixiang Sang |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Male endocrine system Pathology medicine.medical_specialty Poor prognosis Lymph node metastasis Kaplan-Meier Estimate Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Antigen Antigens Neoplasm Stomach Neoplasms Biomarkers Tumor Medicine Humans Stage (cooking) neoplasms Aged Intraepithelial neoplasia Tissue microarray business.industry Cancer Cell Biology Middle Aged medicine.disease Prognosis Neoplasm Proteins 030104 developmental biology 030220 oncology & carcinogenesis Disease Progression Immunohistochemistry Female business |
| Zdroj: | Pathology, research and practice. 213(8) |
| ISSN: | 1618-0631 |
| Popis: | Background As the best characterized CTA family members, melanoma-associated antigens (MAGE) have been reported to express in various malignant tumors. However, the expression pattern of MAGE-A family in gastric cancer (GC) specimens and their prognostic and therapeutic significance for GC patients is still unclear. Materials and methods Tissue microarray − based immunohistochemistry analysis was used to examine the expression of MAGE-A family members (including MAGE-A1, −A2, −A3, −A4, −A6, −A10, and −A12) in 86 cases of GC specimens, 20 cases of the corresponding adjacent normal gastric specimens, and 9 cases of intraepithelial neoplasia specimens. The association between MAGE-A expression and the clinicopathological parameters as well as the 5-year overall survival of GC patients was analyzed. Results 54.7% of GC specimens showed positive MAGE-A expression. In the adjacent normal gastric specimens, MAGE-A was not expressed in the normal surface mucous cells, but expressed in some normal fundic glands. In addition, MAGE-A expression was also detected in intraepithelial neoplasia specimens. In GC specimens, MAGE-A expression was associated with lymph node metastasis, poor differentiation, and high clinical TNM stage. MAGE-A expression was also correlated with the poor 5-year overall survival of GC patients. However, MAGE-A expression is not an independent prognostic factor for GC patients. Conclusions MAGE-A family may be involved in the gastric cancer progression, and their expression could be considered to improve the prognostic evaluation for GC patients. |
| Databáze: | OpenAIRE |
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