A randomized study of surgical site infiltration with bupivacaine or ketamine for pain relief in children following cleft palate repair
| Autor: | Ramesh Kumar Sharma, Ajay Kumar Jha, Sandhya Yaddanapudi, Jai Kumar Mahajan, Neerja Bhardwaj |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Nausea medicine.medical_treatment Sedation Analgesic Child Behavior Kaplan-Meier Estimate Postoperative Complications Double-Blind Method medicine Humans Ketamine Anesthetics Local Child Pain Measurement Bupivacaine Anesthetics Dissociative Pain Postoperative Local anesthetic business.industry Infant Surgery Tonsillectomy Cleft Palate Anesthesiology and Pain Medicine Palatoplasty Treatment Outcome Anesthesia Child Preschool Pediatrics Perinatology and Child Health Postoperative Nausea and Vomiting Female medicine.symptom business Deglutition Disorders Sleep medicine.drug Anesthesia Local |
| Zdroj: | Paediatric anaesthesia. 23(5) |
| ISSN: | 1460-9592 |
| Popis: | Summary Background Wound infiltration with ketamine reduces postoperative pain after tonsillectomy by NMDA receptor blockade and local anesthetic effect. Objectives To evaluate the postoperative analgesia after surgical site infiltration with bupivacaine or ketamine in children undergoing cleft palate surgery. Materials and methods After institutional ethics committee approval and parental consent, 50 ASA-1 children of age 1–6 years undergoing palatoplasty were included in this prospective randomized double-blind study. A standardized technique of general anesthesia was used. The surgical site was infiltrated with either 2 mg·kg−1 of bupivacaine (Group B) or 0.5 mg·kg−1 of ketamine (Group K). Pain (Children Hospital Eastern Ontario Pain Score), sedation, dysphagia, nausea, vomiting, and sleep pattern were assessed postoperatively up to 24 h. Results CHEOPS scores were similar in both the groups up to 12 h but were lower with ketamine compared with bupivacaine at 24 h postoperatively (P = 0.01). Fewer children required rescue analgesics in Group K (28%) than in Group B (64%; P |
| Databáze: | OpenAIRE |
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