The diagnostic accuracy of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in mediastinal tuberculous lymphadenitis
| Autor: | Serir Aktogu, Serhat Erol, Can Biçmen, Zekiye Aydoğdu, Ceyda Anar, Onur Fevzi Erer |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Tuberculosis Mediastinal lymphadenopathy Tuberculosis Lymph Node 030226 pharmacology & pharmacy 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests medicine Mediastinal Diseases Humans Lymphadenitis tuberculosis mediastinal diseases endobronchial ultrasound Endoscopic Ultrasound-Guided Fine Needle Aspiration Aged Retrospective Studies business.industry Mediastinum Retrospective cohort study General Medicine Middle Aged medicine.disease Tuberculous lymphadenitis medicine.anatomical_structure 030228 respiratory system Predictive value of tests Etiology Female Radiology Lymph Nodes business |
| Zdroj: | Volume: 47, Issue: 6 1874-1879 Turkish Journal of Medical Sciences |
| ISSN: | 1300-0144 1303-6165 |
| Popis: | Background/aim: Mediastinal lymph nodes are the second most commonly affected lymph nodes in tuberculous lymphadenitis. It is often difficult to diagnose tuberculosis in patients with lymphadenopathy without parenchymal lesions. The aim of this study was to describe the diagnostic utility of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in patients with isolated mediastinal tuberculous lymphadenitis (MTLA). Materials and methods: This study included 527 patients who had undergone EBUS-TBNA between December 2012 and December 2014. Patients with the final diagnosis of MTLA were evaluated. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of EBUS-TBNA were calculated.Results: The prevalence of MTLA in all patients who had undergone EBUS-TBNA for mediastinal lymphadenopathy of unknown etiology was 5.2% (28/527). EBUS-TBNA was diagnostic in 21/28 (75%) patients, and the remaining 7 patients required additional procedures for confirmation of diagnosis. Sensitivity, specificity, PPV, NPV, and accuracy of combined cytopathological and microbiological examinations of EBUS-TBNA in the diagnosis of MTLA were 87.5%, 98.5%, 91.4%, 98%, and 94.4%, respectively. There were no major complications.Conclusion: EBUS-TBNA is a safe and effective procedure for the diagnosis of MTLA. When microbiological and cytopathological examinations of samples are combined, EBUS-TBNA demonstrates good diagnostic accuracy and NPV for the diagnosis of MTLA. |
| Databáze: | OpenAIRE |
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