Effects of anti-osteoporosis medications on radiological and clinical results after acute osteoporotic spinal fractures: a retrospective analysis of prospectively designed study
| Autor: | Ahn Jh, Seo Jy, Kim Yy, Kee-Yong Ha, Dong-Gune Chang, Cho Jh, Sun Kim, Young Hoon Kim, Park Hy, Min Hk, Oh Is, Kee-Won Rhyu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Osteoporosis 030209 endocrinology & metabolism 03 medical and health sciences 0302 clinical medicine Anabolic Agents Risk Factors Internal medicine Spinal fracture medicine Teriparatide Humans Aged Retrospective Studies Aged 80 and over Fracture Healing Bone Density Conservation Agents business.industry Odds ratio Bisphosphonate Middle Aged medicine.disease Magnetic Resonance Imaging Rheumatology Oswestry Disability Index Radiography Orthopedic surgery Acute Disease Spinal Fractures Female 030101 anatomy & morphology business Osteoporotic Fractures medicine.drug |
| Zdroj: | Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 30(11) |
| ISSN: | 1433-2965 |
| Popis: | Effects of anti-osteoporosis medications such as anti-resorptive and anabolic agents on healing of osteoporotic spinal fracture were retrospectively investigated. The use of anabolic agent significantly enhanced fracture healing, reduced progressive collapse, and presented good pain relief. These findings suggest that proper selection of medication could improve initial management of acute osteoporotic spinal fractures (OSFs). Although anti-osteoporosis medications have beneficial effects on prevention of osteoporotic spinal fractures (OSFs), few studies have compared effects of medications on fracture healing following OSFs. Therefore, the purpose of this study was to elucidate the effects of different anti-osteoporosis medications on radiological and clinical outcomes after acute OSFs. A total of 132 patients diagnosed with acute OSFs were enrolled and allocated into three groups [group I (n = 39, no anti-osteoporosis medication), group II (n = 66, bisphosphonate), and group III (n = 27, parathyroid hormone (PTH)]. Radiological parameters including magnetic resonance (MR) classification, occurrence of intravertebral cleft (IVC), and clinical outcomes such as numerical rating scale (NRS) and Oswestry disability index were assessed. Risk analyses for IVC and progressive collapse were done along the related factors and medication type. IVC sign was observed in 30 patients. The rate of IVC sign was lower in group III (7.4%) than that in group I (20.5%) or group II (30.3%), although the difference was not statistically significant. Moreover, the degree of NRS improvement was better in group III than that in group I or group II (5.7 vs. 3.1 vs. 3.5, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink