Study of the relationship between the expression of nerve growth factor and aneurysm formation and prognosis
| Autor: | Yitao Wang, Zhenghang Wang, Changming Wang, Cao Pc, Zie Wang, Wang Dk |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Pathology Aneurysm Text mining Western blot Nerve Growth Factor Genetics Medicine Humans cardiovascular diseases Aneurysm formation Molecular Biology Computed tomography angiography Aged medicine.diagnostic_test business.industry Intracranial Aneurysm General Medicine Anatomy Middle Aged medicine.disease Prognosis Cerebral Angiography Nerve growth factor nervous system cardiovascular system Histopathology Female business Tomography X-Ray Computed Cerebral angiography |
| Zdroj: | Genetics and molecular research : GMR. 14(2) |
| ISSN: | 1676-5680 |
| Popis: | We sought to investigate the effect of nerve growth factor (NGF) expression on the formation and prognosis of cerebral aneurysms. Forty-eight cases were selected following a diagnosis of cerebral aneurysm using computed tomography angiography and surgical confirmation. Thirty-four cases of healthy deaths were also chosen. The tissue was tested for NGF expression changes by reverse-transcription PCR, Western blot and histopathology, and NGF expression was compared between the cerebral aneurysm and healthy groups. The expression level of NGF in cerebral aneurysm tissue was significantly increased over that observed in control tissue. The abnormal expression of NGF is related to cerebral aneurysms. The elevated expression of NGF in cerebral aneurysms may be associated with a poor prognosis. |
| Databáze: | OpenAIRE |
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