Association between Tau polymorphism and male early-onset Alzheimer’s disease
| ISSN: | 0959-4965 |
|---|---|
| DOI: | 10.1097/00001756-200401190-00034 |
| Přístupová URL adresa: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::504307162a39804f671c360f2d18e79d https://doi.org/10.1097/00001756-200401190-00034 |
| Přírůstkové číslo: | edsair.doi.dedup.....504307162a39804f671c360f2d18e79d |
| Autor: | Takeshi Tabira, Takashi Asada, Hiroshi Tanahashi |
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Genotype Molecular Sequence Data Tau protein tau Proteins Sex Factors Degenerative disease Alzheimer Disease mental disorders medicine Humans Early-onset Alzheimer's disease Amino Acid Sequence Age of Onset Allele Aged Aged 80 and over Polymorphism Genetic biology General Neuroscience Age Factors Neurofibrillary tangle Odds ratio Middle Aged medicine.disease Case-Control Studies Immunology biology.protein Female Age of onset Alzheimer's disease Psychology |
| Zdroj: | NeuroReport. 15:175-179 |
| ISSN: | 0959-4965 |
| DOI: | 10.1097/00001756-200401190-00034 |
| Popis: | Neurofibrillary tangles, containing hyperphosphorylated microtubule-associated protein tau, are one of the major pathological hallmarks of Alzheimer's disease. To investigate a possible association between tau genotypes and the risk of Alzheimer's disease, we screened for polymorphisms in the tau gene and found a novel polymorphism IVS11 + 90G --> A. A case-control study (874 patients and 678 controls) showed a significant association between possession of the A allele and male Alzheimer's disease with early-onset (age of onset before 65, odds ratio = 2.65; 95% confidence interval 1.30-5.42), suggesting that age and gender modify the risk effect. However, we failed to replicate the reported association between the Saitohin gene located in the tau intron 9 and Japanese Alzheimer's disease. |
| Databáze: | OpenAIRE |
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