Assessment of KRAS G12C Target Engagement by a Covalent Inhibitor in Tumor Biopsies Using an Ultra-Sensitive Immunoaffinity 2D-LC-MS/MS Approach

Autor:	Lingyao Meng, Emily W. Chan, Carl Ng, Junko Aimi, John C. Tran, Angela J. Oh, Mark Merchant, Hans E. Purkey, Timothy P. Heffron, Surinder Kaur, Keyang Xu, Zhen Shi, Jintang He
Rok vydání:	2022
Předmět:	Proto-Oncogene Proteins p21(ras) Lung Neoplasms Tandem Mass Spectrometry Biopsy Carcinoma Non-Small-Cell Lung Mutation Animals Humans Antineoplastic Agents Guanosine Triphosphate Analytical Chemistry Chromatography Liquid
Zdroj:	Analytical chemistry. 94(37)
ISSN:	1520-6882
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::504287de6a6fc7658756ee7a60730321 https://pubmed.ncbi.nlm.nih.gov/36083155 Zobrazit plný text záznamu