End-functionalised 1-vinyl-2-pyrrolidinone oligomers bearing lactate functions at one end
| Autor: | Paolo Ferruti, Luca Macchi, Rita Annunziata, Elisabetta Ranucci, Federica Chiellini |
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| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
BALB 3T3 Cells
Magnetic Resonance Spectroscopy Polymers and Plastics Radical polymerization Bioengineering Biocompatible Materials Oligomer Biomaterials chemistry.chemical_compound Mice Polymer chemistry Materials Chemistry Animals Carbon Isotopes Molecular mass Molecular Structure Chain transfer Carbon-13 NMR Pyrrolidinones Culture Media Molecular Weight End-group chemistry Polymerization Functional group Lactates Solvents Polyvinyls Biotechnology |
| Popis: | 1-Vinyl-2-pyrrolidinone (VP) oligomers bearing a lactate group at one end (PVP-L) were obtained by chain-transfer controlled radical polymerisation carried out in the presence of ethyl L-lactate as chain-transfer agent (CTA). Their number-average molecular weights were in the range 1500-4000 with molecular weight distributions ranging from 1.4 to 1.8. The chain transfer constant, C T , of the ethyl L-lactate/VP system was determined by monitoring the variation of PVP-L number-average molecular weight on conversion. The C T value so obtained was 1.03 x 10 -2 , which is by about one order of magnitude higher than the C T value previously determined for a seemingly similar system, namely methyl isobutyrate/1-vinyl-2-pyrrolidinone (1.64 x 10 -3 ). The resultant PVP-L oligomers were thoroughly characterised by means of 1 H and 13 C NMR, in order to ascertain the regular presence of the lactate functions at one of their chain terminals. NMR characterisations gave results in full agreement with the proposed structure. Moreover, the molecular weight values determined by NMR very closely agreed with those obtained by SEC. Preliminary biological evaluations of the PVP-L oligomers showed a complete lack of toxicity. |
| Databáze: | OpenAIRE |
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