The quality of the antioxidant defence system in term and preterm twin neonates
| Autor: | Hajnalka Orvos, Renáta Lázár, Reka Szőllősi, Ilona Sz Varga |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Antioxidant Physiology medicine.medical_treatment Clinical Biochemistry Twins Gestational Age medicine.disease_cause Biochemistry Antioxidants Protein Carbonylation Lipid peroxidation Superoxide dismutase chemistry.chemical_compound Pregnancy Internal medicine medicine Humans Research Articles chemistry.chemical_classification Glutathione Peroxidase Reactive oxygen species biology Superoxide Dismutase Glutathione peroxidase Biochemistry (medical) Infant Newborn Cell Biology Glutathione Catalase Fetal Blood Endocrinology chemistry biology.protein Female Lipid Peroxidation Infant Premature Oxidative stress |
| Zdroj: | Redox Report. 20:103-108 |
| ISSN: | 1743-2928 1351-0002 |
| DOI: | 10.1179/1351000214y.0000000111 |
| Popis: | Objective: Multiple pregnancy is associated with an enhanced metabolism and demand for O2, which may lead to the overproduction of reactive oxygen species and the development of oxidative stress. The degree of oxidative damage depends on the level of the antioxidant protection system of the foetus. The objective of the study was to identify the relationship between the state of the maturity and the antioxidant status of twin neonates. Investigations of the umbilical cord blood were carried out to detect differences in the antioxidant defence system between mature and premature twin neonates. Methods: The activities of the superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) enzymes, the levels of reduced glutathione (GSH), protein carbonyls and oxidized lipids and the total antioxidant capacity of the plasma were determined. Results: The level of lipid peroxidation was significantly higher in the premature neonates. An increase in the total antioxidant capacity was accompanied by a decrease in the damaged protein concentration. Significantly elevated activities of GPx alone were observed in the premature twins, though the GSH content too tended to be increased. The activity of SOD was decreased in the premature neonates. Discussion: The antioxidant status of twin neonates are mainly influenced by maturity. We suggest that the level of lipid peroxidation might be of clinical value as a marker of pre- and perinatal distress in twins. |
| Databáze: | OpenAIRE |
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