GluN2A- and GluN2B-immunoreactive type I cells attached to vesicular glutamate transporter 2-immunoreactive afferent nerve terminals of the rat carotid body

Autor:	Takuya Yokoyama, Yoshio Yamamoto, Tomoyuki Saino, Masato Hirakawa
Rok vydání:	2021
Předmět:	Male 0301 basic medicine Histology Chemoreceptor Glutamic Acid Receptors N-Methyl-D-Aspartate Exocytosis 03 medical and health sciences Dopamine medicine Animals Rats Wistar Tyrosine Receptor Molecular Biology Nerve Endings Carotid Body 030102 biochemistry & molecular biology Chemistry Glutamate receptor Cell Biology Rats Cell biology Medical Laboratory Technology 030104 developmental biology medicine.anatomical_structure Vesicular Glutamate Transport Protein 2 NMDA receptor Carotid body medicine.drug
Zdroj:	Histochemistry and Cell Biology. 155:719-726
ISSN:	1432-119X 0948-6143
Popis:	We previously reported the immunoreactivity for the vesicular glutamate transporter 2 (VGLUT2) in afferent nerve terminals attached to chemoreceptor type I cells of the carotid body (CB), suggesting that glutamate is released from afferent terminals to stimulate these cells. In the present study, we examined the immunoreactivity for the glutamate-binding subunits of N-methyl-D-aspartate (NMDA) receptors, GluN2A and GluN2B in the rat CB, and the immunohistochemical relationships between these subunits and VGLUT2. Immunoreactivities for GluN2A and GluN2B were predominant in a subpopulation of tyrosine hydroxylase-immunoreactive type I cells rather than those of dopamine beta-hydroxylase-immunoreactive cells. Punctate VGLUT2-immunoreactive products were attached to GluN2A- and GluN2B-immunoreactive type I cells. Bassoon-immunoreactive products were localized between VGLUT2-immunoreactive puncta and type I cells immunoreactive for GluN2A and GluN2B. These results suggest that afferent nerve terminals release glutamate by exocytosis to modulate chemosensory activity of a subpopulation of type I cells via GluN2A- and GluN2B subunits-containing NMDA receptors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::503b8a07b28f361ef00b9ac852f05054 https://doi.org/10.1007/s00418-021-01970-5 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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