Foetal loss and infant deaths in families of children with soft-tissue sarcoma
| Autor: | Valerie Blair, Patricia H. Morris Jones, Ann L. Hartley, Jillian M Birch, Anna Kelsey |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Cancer Research
medicine.medical_specialty Pathology Adolescent Neurofibromatoses Population Soft Tissue Neoplasms Li-Fraumeni Syndrome Pregnancy Infant Mortality Rhabdomyosarcoma medicine Genetic predisposition Humans Family Neurofibromatosis Child education Fetal Death Index case education.field_of_study Obstetrics business.industry Soft tissue sarcoma Infant Newborn Infant Sarcoma medicine.disease Infant mortality Abortion Spontaneous Oncology Li–Fraumeni syndrome Child Preschool Female Disease Susceptibility business Maternal Age |
| Zdroj: | International Journal of Cancer. 56:646-649 |
| ISSN: | 1097-0215 0020-7136 |
| Popis: | Distribution of miscarriages, stillbirths and infant deaths in the families of a population-based series of children with soft-tissue sarcoma was examined in relation to index case histology (rhabdomyosarcoma or other soft-tissue sarcoma) and to the possible presence of genetic predisposition to cancer in the families (Li-Fraumeni syndrome or neurofibromatosis). Reproductive loss was not related to index histology (miscarriages, p = 0.3; all losses, p = 0.6) but was significantly higher in "genetic" rather than "sporadic" families (miscarriages, p = 0.02; all losses, p = 0.01). However, excess reproductive loss was not a feature of families with the Li-Fraumeni syndrome, but appeared to be concentrated in the families affected by neurofibromatosis. |
| Databáze: | OpenAIRE |
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