Disruption of posterior brain functional connectivity and its relation to cognitive impairment in idiopathic REM sleep behavior disorder

Autor: Carme Uribe, Carme Junqué, A. Iranzo, Mónica Serradell, Alexandra Abos, Carles Gaig, Núria Bargalló, Anna Campabadal, Barbara Segura, Joan Santamaria, Yaroslau Compta, Hugo C. Baggio
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
medicine.medical_specialty
Parkinson's disease
Cognitive Neuroscience
REM Sleep Behavior Disorder
lcsh:Computer applications to medicine. Medical informatics
REM sleep behavior disorder
050105 experimental psychology
lcsh:RC346-429
Graph
03 medical and health sciences
0302 clinical medicine
Physical medicine and rehabilitation
Cognition
Magnetic resonance imaging
Imatges per ressonància magnètica
Neural Pathways
medicine
Connectome
Humans
0501 psychology and cognitive sciences
Radiology
Nuclear Medicine and imaging
Cognitive Dysfunction
Idiopathic REM behavior disorder
lcsh:Neurology. Diseases of the nervous system
Aged
Trastorns del son
Synucleinopathies
Resting state fMRI
business.industry
Functional connectivity
05 social sciences
Brain
Regular Article
Sleep disorders
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Neurology
Biomarker (medicine)
lcsh:R858-859.7
Female
Neurology (clinical)
business
030217 neurology & neurosurgery
Zdroj: Dipòsit Digital de la UB
Universidad de Barcelona
NeuroImage : Clinical
NeuroImage: Clinical, Vol 25, Iss, Pp-(2020)
Popis: Highlights • There is a reduced brain posterior functional connectivity in IRBD patients. • Reduced temporo-parietal connectivity correlates with mental processing slowness. • Left superior parietal lobule has reduced centrality in IRBD patients.
Background Resting-state functional MRI has been proposed as a new biomarker of prodromal neurodegenerative disorders, but it has been poorly investigated in the idiopathic form of rapid-eye-movement sleep behavior disorder (IRBD), a clinical harbinger of subsequent synucleinopathy. Particularly, a complex-network approach has not been tested to study brain functional connectivity in IRBD patients. Objectives The aim of the current work is to characterize resting-state functional connectivity in IRBD patients using a complex-network approach and to determine its possible relation to cognitive impairment. Method Twenty patients with IRBD and 27 matched healthy controls (HC) underwent resting-state functional MRI with a 3T scanner and a comprehensive neuropsychological battery. The functional connectome was studied using threshold-free network-based statistics. Global and local network parameters were calculated based on graph theory and compared between groups. Head motion, age and sex were introduced as covariates in all analyses. Results IRBD patients showed reduced cortico-cortical functional connectivity strength in comparison with HC in edges located in posterior regions (p
Databáze: OpenAIRE
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