Evaluation of spermatozoa of the rat in hyperprolactinaemia induced by Metoclopramide
| Autor: | Rózewicka L, M Kuchnio, Mariola Marchlewicz, Małgorzata Piasecka, Maria Laszczyńska |
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| Rok vydání: | 2009 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Metoclopramide Urology Lumen (anatomy) Semen Biology Endocrinology Reference Values Internal medicine medicine Animals reproductive and urinary physiology Cell Nucleus Epididymis urogenital system Hyperprolactinaemia Rats Inbred Strains General Medicine Seminiferous Tubules medicine.disease Spermatozoa Epithelium Prolactin Rats Hyperprolactinemia Microscopy Electron medicine.anatomical_structure Duct (anatomy) medicine.drug |
| Zdroj: | Andrologia. 24:101-108 |
| ISSN: | 1439-0272 0303-4569 |
| DOI: | 10.1111/j.1439-0272.1992.tb02618.x |
| Popis: | Metoclopramide (MCP) in doses of 2.2 mg kg-1 body weight, being administered intraperitoneally to rats for 14 d, provokes a premature release of germ cells in the testes. The number of spermatozoa is reduced. In addition the spermatozoa exhibit defects of head and tail structures. After the administration of MCP for 14 d, followed by a 14-d break in applying the drug, the number of spermatozoa in the lumen of the epididymal duct continues to be low. Many spermatozoa are damaged. Only after a 66-d-break in MCP administration is the morphology of the seminiferous epithelium restored, and a large number of spermatozoa appear in the lumen of the epididymal duct. |
| Databáze: | OpenAIRE |
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