Physical exercise modifies behavioral and molecular parameters related to opioid addiction regardless of training time
| Autor: | Marilise Escobar Burger, H.J. Segat, Verônica Tironi Dias, H.Z. Rosa, Laura Hautrive Milanesi, Kr. Roversi, Raquel Cristine Silva Barcelos |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Time Factors media_common.quotation_subject Physical exercise Nucleus accumbens 03 medical and health sciences 0302 clinical medicine Physical Conditioning Animal Internal medicine Dopamine receptor D2 Conditioning Psychological medicine Animals Pharmacology (medical) Rats Wistar Swimming Biological Psychiatry Dopamine transporter media_common computer.programming_language Pharmacology Morphine biology business.industry sed Addiction Opioid-Related Disorders Rats 030227 psychiatry Psychiatry and Mental health Endocrinology Neurology Opioid Dopamine receptor biology.protein Neurology (clinical) Sedentary Behavior business computer 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | European Neuropsychopharmacology. 32:25-35 |
| ISSN: | 0924-977X |
| DOI: | 10.1016/j.euroneuro.2019.12.111 |
| Popis: | Addiction is a devastating worldwide disorder that requires effective and innovative therapies. Physical exercise could be useful in addiction treatment because it shares a common neural circuit with addictive drugs. Based on this, molecular adaptations consequent to time of exercise in opioid exposed animals were evaluated. Rats were designed as sedentary (SED) or exercised (EXE). This last group was separated to perform three different periods of swimming: short-term (S-EXE), medium-term (M-EXE) and long-term (L-EXE) for 14, 28 and 42 days, respectively. On the last exercising week, one-half of the animals from SED and all animals from S-, M- and l-EXE were concomitantly exposed to morphine-conditioned place preference (CPP) paradigm and y-maze task for behavioral assessments followed by molecular assays in both Nucleus accumbens (NAc) and hippocampus. Between SED groups, morphine conditioning showed drug-CPP and increased dopamine transporter (DAT), dopamine receptor type-1 (D1R), type-2 (D2R) and glucocorticoid receptor (GR) in both brain areas in relation to saline group. Besides the small morphine-CPP in relation to SED group, all periods decreased DAT, D1R, and GR immunoreactivity in NAc, DAT and D1R in hippocampus, while D2R in both brain areas and GR in hippocampus were primarily decreased by L-EXE. Our findings show that even a short-term exercise modifies behaviors related to drug withdrawal, changing DA targets and GR, which are closely linked to addiction. Therefore, our outcomes involving physical exercise are interesting to perform a possible clinical trial, thus expanding the knowledge about drug addiction. |
| Databáze: | OpenAIRE |
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