Roles of microRNAs in inflammatory bowel disease
| Autor: | Salvatore Terrazzino, Andreas Kronbichler, Min Seo Kim, Keum Hwa Lee, Sarah Cargnin, Ai Koyanagi, Sung Hwi Hong, Jaeseok Kim, Lee Smith, Louis Jacob, Seung Won Lee, Paul Wasuwanich, Kalthoum Tizaoui, Han Li, Wikrom Karnsakul, Dong Keon Yon, Jae Il Shin, HyunTaek Jung |
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| Rok vydání: | 2021 |
| Předmět: |
Review
Applied Microbiology and Biotechnology Inflammatory bowel disease Pathogenesis 03 medical and health sciences Immune system Drug Development microRNA Medicine Humans Molecular Biology Ecology Evolution Behavior and Systematics 030304 developmental biology ulcerative colitis 0303 health sciences Crohn's disease Mechanism (biology) business.industry Disease Management Cell Biology medicine.disease Inflammatory Bowel Diseases Ulcerative colitis Intestinal epithelium digestive system diseases MicroRNAs Gene Expression Regulation Immunology business Developmental Biology Signal Transduction |
| Zdroj: | International Journal of Biological Sciences |
| ISSN: | 1449-2288 |
| Popis: | Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract that mainly affects young people. IBD is associated with various gastrointestinal symptoms, and thus, affects the quality of life of patients. Currently, the pathogenesis of IBD is poorly understood. Although intestinal bacteria and host immune response are thought to be major factors in its pathogenesis, a sufficient explanation of their role in its pathophysiologic mechanism has not been presented. MicroRNAs (miRNAs), which are small RNA molecules that regulate gene expression, have gained attention as they are known to participate in the molecular interactions of IBD. Recent studies have confirmed the important role of miRNAs in targeting certain molecules in signaling pathways that regulate the homeostasis of the intestinal barrier, inflammatory reactions, and autophagy of the intestinal epithelium. Several studies have identified the specific miRNAs associated with IBD from colon tissues or serum samples of IBD patients and have attempted to use them as useful diagnostic biomarkers. Furthermore, some studies have attempted to treat IBD through intracolonic administration of specific miRNAs in the form of nanoparticle. This review summarizes the latest findings on the role of miRNAs in the pathogenesis, diagnosis, and treatment of IBD. |
| Databáze: | OpenAIRE |
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