Consolidative Radiotherapy After Autologous Stem Cell Transplantation for Relapsed or Refractory Diffuse Large B-cell Lymphoma
| Autor: | Jianling Yuan, Matthew R. Vernon, Kathryn E. Dusenbery, Brendan G. Coutu, Christopher Wilke, Qing Cao, Veronika Bachanova, Chung Lee |
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| Rok vydání: | 2017 |
| Předmět: |
Oncology
Adult Male Cancer Research medicine.medical_specialty Transplantation Conditioning medicine.medical_treatment Transplantation Autologous Article 03 medical and health sciences 0302 clinical medicine Autologous stem-cell transplantation Refractory Internal medicine medicine Refractory Diffuse Large B-Cell Lymphoma Humans Radiation oncologist Aged Chemotherapy business.industry Hematopoietic Stem Cell Transplantation Hematology Total body irradiation Middle Aged medicine.disease Lymphoma Surgery Radiation therapy 030220 oncology & carcinogenesis Female Lymphoma Large B-Cell Diffuse Neoplasm Recurrence Local business 030215 immunology |
| Zdroj: | Clinical lymphoma, myelomaleukemia. 18(1) |
| ISSN: | 2152-2669 |
| Popis: | PURPOSE: To evaluate the role of consolidative radiotherapy in patients undergoing high dose chemotherapy and autologous stem cell transplant for relapsed or refractory diffuse large B-cell lymphoma (DLBCL). METHODS AND MATERIALS: We reviewed the medical records of 72 consecutive patients who underwent autologous stem cell transplant for relapsed or refractory DLBCL at XXXX from 2006 to 2014. Pre-transplant conditioning consisted of high-dose chemotherapy and total body irradiation. Thirteen patients received post-transplant consolidative radiotherapy at the discretion of the consulted radiation oncologist. RESULTS: Consolidative radiotherapy was associated with a significantly improved 2-year locoregional control (LRC) (92% vs 68%, p=0.04) although there was no difference in either the 2-year progression-free survival (PFS) (69% vs 54%, p=0.25) or overall survival (OS) (85% vs 59%, p=0.44). Analysis of the subgroup of 19 patients who had persistent residual masses ≥2 cm on post-transplant imaging demonstrated a significant improvement in the LRC (100% vs 36%, p |
| Databáze: | OpenAIRE |
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