Poor In Utero Growth and Reduced β-Cell Compensation and High Fasting Glucose from Childhood Are Harbingers of Glucose Intolerance in Young Indians
| Autor: | Aboli Bhalerao, Clive Osmond, Pallavi C. Yajnik, Chittaranjan S. Yajnik, Anand Pandit, Dattatray S. Bhat, Souvik Bandopadhyay, Kalyanaraman Kumaran, Kurus Coyaji, Sanat Phatak, Caroline H.D. Fall, Rucha H. Wagh, Sheila Bhave |
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| Rok vydání: | 2021 |
| Předmět: |
Blood Glucose
Male Endocrinology Diabetes and Metabolism medicine.medical_treatment India Physiology Type 2 diabetes Pregnancy Diabetes mellitus Glucose Intolerance Internal Medicine medicine Humans Insulin Prediabetes Young adult Child Advanced and Specialized Nursing business.industry Fasting Glucose Tolerance Test medicine.disease Malnutrition Glucose Diabetes Mellitus Type 2 Female Insulin Resistance Underweight medicine.symptom business |
| DOI: | 10.2337/figshare.16606415.v1 |
| Popis: | OBJECTIVE India is a double world capital of early-life undernutrition and type 2 diabetes. We aimed to characterize life course growth and metabolic trajectories in those developing glucose intolerance as young adults in the Pune Maternal Nutrition Study (PMNS). RESEARCH DESIGN AND METHODS PMNS is a community-based intergenerational birth cohort established in 1993, with serial information on parents and children through pregnancy, childhood, and adolescence. We compared normal glucose-tolerant and glucose-intolerant participants for serial growth, estimates of insulin sensitivity and secretion (HOMA and dynamic indices), and β-cell compensation accounting for prevailing insulin sensitivity. RESULTS At 18 years (N = 619), 37% of men and 20% of women were glucose intolerant (prediabetes n = 184; diabetes n = 1) despite 48% being underweight (BMI CONCLUSIONS Inadequate compensatory insulin secretory response to decreasing insulin sensitivity in early life is the major pathophysiology underlying glucose intolerance in thin rural Indians. Smaller birth size, maternal pregnancy hyperglycemia, and higher glycemia from childhood herald future glucose intolerance, mandating a strategy for diabetes prevention from early life, preferably intergenerationally. |
| Databáze: | OpenAIRE |
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