Maternal high-fat high-sucrose diet and gestational exercise modulate hepatic fat accumulation and liver mitochondrial respiratory capacity in mothers and male offspring
| Autor: | Susana P. Pereira, Maria João Martins, Pedro Coxito, Tiago Bordeira Gaspar, Rossana Correia, Fátima Gärtner, Hugo Rocha, Jelena Stevanović-Silva, Tiago Guimarães, Sandra Martins, Paulo J. Oliveira, António Ascensão, Jorge Beleza, José Magalhães |
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| Přispěvatelé: | Instituto de Saúde Pública da Universidade do Porto |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Sucrose medicine.medical_specialty Offspring Endocrinology Diabetes and Metabolism Cell Respiration Mothers Mitochondria Liver 030209 endocrinology & metabolism Liver mitochondria Diet High-Fat Fetal programming Gestational diabetes Physical activity Pregnancy Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Endocrinology Fat accumulation Physical Conditioning Animal Internal medicine Dietary Carbohydrates medicine Animals Adverse effect Respiratory capacity 2. Zero hunger business.industry Maternal Nutritional Physiological Phenomena High fat high sucrose Lipid Metabolism medicine.disease Rats Diabetes Gestational 030104 developmental biology Liver Prenatal Exposure Delayed Effects Gestation Female business |
| Zdroj: | Metabolism |
| Popis: | Background Maternal high-caloric nutrition and related gestational diabetes mellitus (GDM) are associated with a high-risk for developing metabolic complications later in life and in their offspring. In contrast, exercise is recognized as a non-pharmacological strategy against metabolic dysfunctions associated to lifestyle disorders. Therefore, we investigated whether gestational exercise delays the development of metabolic alterations in GDM mothers later in life, but also protects 6-week-old male offspring from adverse effects of maternal diet. Methods Female Sprague-Dawley rats were fed with either control (C) or high-fat high-sucrose (HFHS) diet to induce GDM and submitted to gestational exercise during the 3 weeks of pregnancy. Male offspring were sedentary and fed with C-diet. Results Sedentary HFHS-fed dams exhibited increased gestational body weight gain (p |
| Databáze: | OpenAIRE |
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