Case Report: Remdesivir and Convalescent Plasma in a Newly Acute B Lymphoblastic Leukemia Diagnosis With Concomitant Sars-CoV-2 Infection
| Autor: | Elena Mastrodicasa, Carla Cerri, Barbara Luciani Pasqua, Matteo Felicioni, Giovanni Battista Dell'Isola, Ilaria Capolsini, Alberto Verrotti, Mariangela Brogna, Grazia Gurdo, Katia Perruccio, Maurizio Caniglia, Maria Speranza Massei, Francesco Arcioni, Paolo Gorello, Luigi Ferraro, Alessandra Mercuri |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Convalescent plasma Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remdesevir Case Report Disease Pediatrics RJ1-570 03 medical and health sciences 0302 clinical medicine Internal medicine SARS–CoV−2 medicine Adverse effect business.industry leukemia COVID-19 Cancer medicine.disease Leukemia 030104 developmental biology 030220 oncology & carcinogenesis Concomitant convalescent plasma Pediatrics Perinatology and Child Health business |
| Zdroj: | Frontiers in Pediatrics Frontiers in Pediatrics, Vol 9 (2021) |
| ISSN: | 2296-2360 |
| DOI: | 10.3389/fped.2021.712603 |
| Popis: | Introduction:The spread of Covid-19 has worsened the prognosis of oncology patients, interrupting or delaying life-saving therapies and contextually increasing the risk of severe SARS-CoV-2 infections. Acute lymphoblastic leukemia (ALL) is the most frequent cancer in pediatric age and the management of this disease with concomitant SARS-COV-2 infection represents a challenging situation.Case presentation:We present the case of a 6-year-old female newly diagnosed with ALL during a documented SARS-CoV-2 infection. Our patient was admitted 20 days after SARS-CoV-2 detection for evening-rise fever. Laboratory testing showed severe neutropenia while chest x-ray detected moderate pulmonary involvement. Acute lymphoblastic leukemia diagnosis was made through morphological and molecular analysis on bone marrow aspirate. Given the stability of the blood count and clinical conditions, antiviral therapy with Remdesivir and Convalescent Plasma was started before antileukemic treatment, obtaining a rapid resolution of the infection.Conclusion:In our experience, the treatment with Remdesivir and Convalescent Plasma led to a rapid resolution of Sars-Cov-2 infection. Our case did not present any adverse event to the therapy. Thus, this treatment could be considered in patients with malignancies, in order to accelerate the resolution of the infection and begin immunosuppressive treatment safely. Further studies are required to confirm this hypothesis. |
| Databáze: | OpenAIRE |
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