A systematic review and meta-analysis study of salivary and serum interleukin-8 levels in oral lichen planus
| Autor: | Sara Montazerian, Roohollah Sharifi, Masoud Sadeghi, Sedigheh Rostami, Hamid Reza Mozaffari, Seyedghasem Mirbahari |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
lcsh:Internal medicine Saliva medicine.medical_specialty Dermatology Cochrane Library Gastroenterology Elevated serum 03 medical and health sciences oral lichen planus stomatognathic system Internal medicine lcsh:Dermatology medicine Immunology and Allergy Interleukin 8 lcsh:RC31-1245 Original Paper saliva business.industry Significant difference interleukin-8 lcsh:RL1-803 medicine.disease Confidence interval stomatognathic diseases 030104 developmental biology Meta-analysis Oral lichen planus business serum |
| Zdroj: | Advances in Dermatology and Allergology, Vol 35, Iss 6, Pp 599-604 (2018) Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii |
| ISSN: | 1642-395X |
| DOI: | 10.5114/ada.2018.77611 |
| Popis: | Introduction Interleukin-8 (IL-8) is an important mediator of the host response to injury and inflammation that the clinical severity of oral lichen planus (OLP) is associated with elevated serum IL-8 levels. Aim To evaluate serum and salivary IL-8 levels of the OLP patients compared with the healthy controls and measurement of IL-8 level in which sample is more valuable. Material and methods Five databases including PubMed/Medline, Web of Science, Science Direct, Cochrane Library and Scopus were searched for the evaluation of serum and salivary IL-8 levels of the OLP patients compared with the healthy controls in the English abstract. The Newcastle-Ottawa Quality Assessment Scale (NOS) was used for checking the quality of the studies. A random-effect model was used for calculating the mean difference (MD) and 95% confidence intervals (CIs). Results Nine studies were included in the meta-analysis. The pooled estimate showed a significant difference between two groups that the salivary IL-8 level in the OLP patients was higher than the healthy controls (MD = 766.32 pg/ml, 95% CI: 394.90–1137.75; p < 0.0001) and also the serum IL-8 level in the OLP patients was higher than the healthy controls (MD = 8.38 pg/ml, 95% CI: 3.32–13.44; p = 0.001). Conclusions The higher levels of IL-8 in saliva compared with serum suggest that measurement of this marker in saliva may be more useful than serum measurements for determining therapeutic and diagnostic aims. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|