Potential role of insulin on the pathogenesis of depression
| Autor: | Xiao Han Zou, Ran Ji Cui, Wei Yang, Li Hua Sun, Bing Jin Li |
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| Rok vydání: | 2020 |
| Předmět: |
Review Artcles
0301 basic medicine Hypothalamo-Hypophyseal System medicine.medical_treatment Pituitary-Adrenal System Review Article Bioinformatics Neuroprotection Pathogenesis 03 medical and health sciences 0302 clinical medicine Neurotrophic factors Animals Humans Insulin Medicine Secretion Receptor Depression (differential diagnoses) Depression business.industry Gastrointestinal Microbiome Cell Biology General Medicine 030104 developmental biology 030220 oncology & carcinogenesis business |
| Zdroj: | Cell Proliferation |
| ISSN: | 1365-2184 0960-7722 |
| Popis: | The regulation of insulin on depression and depression‐like behaviour has been widely reported. Insulin and activation of its receptor can promote learning and memory, affect the hypothalamic‐pituitary‐adrenal axis (HPA) balance, regulate the secretion of neurotrophic factors and neurotransmitters, interact with gastrointestinal microbiome, exert neuroprotective effects and have an impact on depression. However, the role of insulin on depression remains largely unclear. Therefore, in this review, we summarized the potential role of insulin on depression. It may provide new insight for clarifying role of insulin on the pathogenesis of depression. |
| Databáze: | OpenAIRE |
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