Photostability of piroxicam in the inclusion complex with 2-hydroxypropyl-β-cyclodextrin
| Autor: | S Aleksandar Zdravkovic, Mirjana Popsavin, D Vesna Nikolic, B Ljubisa Nikolic, D Milorad Cakic, J Agnes Kapor, Snežana Ilić-Stojanović |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
piroxicam
Coprecipitation Chemistry 2-hydroxypropyl-β-cyclodextrin General Chemical Engineering Infrared spectroscopy General Chemistry lcsh:Chemical technology Piroxicam 2 hydroxypropyl β cyclodextrin Photosensitivity medicine Proton NMR Organic chemistry lcsh:TP1-1185 photodegradation Fourier transform infrared spectroscopy Photodegradation inclusion complex medicine.drug Nuclear chemistry |
| Zdroj: | Hemijska Industrija, Vol 68, Iss 1, Pp 107-116 (2014) Hemijska industrija (2014) 68(1):107-116 |
| ISSN: | 0367-598X |
| Popis: | The aim of this work is the protection of piroxicam from photodegradation by forming inclusion complex with 2-hydroxypropyl-?-cyclodextrin. Piroxicam:2-hydroxypropyl-?-cyclodextrin molecular inclusion complex was prepared by coprecipitation method with molar ratio of 1:1. Structural characterization of the complex, the corresponding physical mixture and complexing agents of piroxicam and 2-hydroxypropyl-?-cyclodextrin was carried out by X-ray diffraction (XRD), proton nuclear magnetic resonance (1H NMR) and Fourier transform infrared spectroscopy (FTIR). Photosensitivity to daylight for piroxicam and piroxicam:2-hydroxypropyl-?-cyclodextrin inclusion complex was investigated by Fourier-transform infrared spectroscopy. The investigations show that higher photostability of piroxicam was achieved in complex than in non-complexed piroxicam. |
| Databáze: | OpenAIRE |
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