Borna disease virus-specific T cells protect against or cause immunopathological Borna disease
| Autor: | A. Schmeel, K. Frese, Rudolf Rott, J A Richt, Opendra Narayan, K M Carbone |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
CD4-Positive T-Lymphocytes
Adoptive cell transfer Borna disease animal diseases viruses Immunology virus diseases T lymphocyte Articles Biology Virology Immunotherapy Adoptive Virus Rats Immune system Viral replication Immunization Borna Disease Rats Inbred Lew Immunology and Allergy Animals Viral disease Borna disease virus |
| Zdroj: | The Journal of Experimental Medicine |
| ISSN: | 0022-1007 |
| Popis: | In this report we show that passive immunization of Lewis rats with viable CD4+, Borna disease virus (BDV)-specific T cells before infection with BDV resulted in protection against BD, whereas inoculation of these T cells after BDV infection induced clinical disease with more rapid onset than seen in BDV control animals. The protective as well as encephalitogenic effector functions of BDV-specific CD4+ T cells were mediated only by viable BDV-specific T cells. The protective situation was obtained by passive transfer of BDV-specific T cells into animals inoculated later with virus, whereas the immunopathological situation was observed when virus-specific T cells developed normally or after adoptive transfer, and appeared on the scene after considerable virus replication in the brain. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|