Age-specific values of Access anti-Müllerian hormone immunoassay carried out on Japanese patients with infertility: a retrospective large-scale study

Autor: Masako Kuroda, Masaki Handa, Kenji Omi, Osamu Miyauchi, Yoshiaki Watanabe, Yaeko Sone, S. Teramoto, Hisao Osada, Tomoya Segawa
Rok vydání: 2018
Předmět:
Infertility
Adult
Anti-Mullerian Hormone
medicine.medical_specialty
Reproductive medicine
Fertilization in Vitro
Anti-Müllerian hormone
Automated assay
lcsh:Gynecology and obstetrics
Access immunoassay system
03 medical and health sciences
0302 clinical medicine
Japan
Reference Values
medicine
American population
Humans
030212 general & internal medicine
Ovarian reserve
Ovarian Reserve
lcsh:RG1-991
Retrospective Studies
Immunoassay
Beckman coulter
030219 obstetrics & reproductive medicine
biology
medicine.diagnostic_test
Obstetrics
business.industry
lcsh:Public aspects of medicine
Age-specific values
Obstetrics and Gynecology
lcsh:RA1-1270
Diagnostic marker
General Medicine
Middle Aged
medicine.disease
Age specific
Reproductive Medicine
Japanese
biology.protein
Female
business
Infertility
Female
Zdroj: BMC Women's Health, Vol 19, Iss 1, Pp 1-6 (2019)
ISSN: 1472-6874
Popis: Background The ovarian reserve in women is known to correlate with anti-Müllerian hormone (AMH) levels, and currently the latest, third-generation, fully-automated AMH immunoassays, such as Access and Cobas, are beginning to be used for measuring AMH levels. However, the age-specific reference values obtained for AMH levels have been based on samples from an American population, measured using first-generation immunoassays. In this study, we attempted to determine the age-specific AMH reference values based on a large set of samples taken from Japanese infertile women measured by Access so that they could be used by infertility centers treating Japanese and those with similar racial and life-style characteristics. Methods The study included 5483 Japanese patients who enrolled in infertility treatment programs at two in-vitro fertilization centers, Shimbashi YUME Clinic and Natural ART Clinic Nihombashi in Tokyo, and who had their serum AMH levels measured between December 2015 and November 2017 by Access. Each patient was represented only once in the study. The mean, median, and standard deviation values were obtained from the measured values for single-year intervals from 28 through 48 years of age (21 age groups in total). The 3D-fitted curve of age-specific mean and median values measured by Access was obtained by regression analysis. Results The mean and median values decreased with advancing age (mean: R2 = 0.9864; median: R2 = 0.9926). In all age groups, the mean values were higher than the median values; however, the differences between these values decreased with increasing age. Conclusions The age-specific AMH reference values measured by Access in this study may serve as a useful diagnostic marker in infertility centers, especially those treating Japanese patients or patients with similar characteristics.
Databáze: OpenAIRE
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