The Correlation between Chitin and Acidic Mammalian Chitinase in Animal Models of Allergic Asthma
| Autor: | Ming-Ling Kuo, Horng-Heng Juang, Chao-Lin Liu, Jeen-Kuan Chen, Meng-Hua Lee, Chia-Jen Wu, Ya-Shan Chen, Hui-Shan Chen, Yih-Shiou Hwang, Ching-Jen Yang, Chia-Rui Shen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Allergy
Inflammation Chitin Biology medicine.disease_cause Catalysis Article Arthropod Proteins Cell Line Inorganic Chemistry lcsh:Chemistry Mice Allergen Immune system Genes Reporter medicine Eosinophilia Animals Antigens Dermatophagoides Physical and Theoretical Chemistry Promoter Regions Genetic Molecular Biology Lung lcsh:QH301-705.5 Spectroscopy Asthma promoter Organic Chemistry Chitinases General Medicine Allergens respiratory system asthma medicine.disease allergy Computer Science Applications respiratory tract diseases Ovalbumin Disease Models Animal chitinase Gene Expression Regulation lcsh:Biology (General) lcsh:QD1-999 Immunology Chitinase biology.protein medicine.symptom |
| Zdroj: | International Journal of Molecular Sciences, Vol 16, Iss 11, Pp 27371-27377 (2015) International Journal of Molecular Sciences International Journal of Molecular Sciences; Volume 16; Issue 11; Pages: 27371-27377 |
| ISSN: | 1422-0067 |
| Popis: | Asthma is the result of chronic inflammation of the airways which subsequently results in airway hyper-responsiveness and airflow obstruction. It has been shown that an elicited expression of acidic mammalian chitinase (AMCase) may be involved in the pathogenesis of asthma. Our recent study has demonstrated that the specific suppression of elevated AMCase leads to reduced eosinophilia and Th2-mediated immune responses in an ovalbumin (OVA)-sensitized mouse model of allergic asthma. In the current study, we show that the elicited expression of AMCase in the lung tissues of both ovalbumin- and Der P2-induced allergic asthma mouse models. The effects of allergic mediated molecules on AMCase expression were evaluated by utilizing promoter assay in the lung cells. In fact, the exposure of chitin, a polymerized sugar and the fundamental component of the major allergen mite and several of the inflammatory mediators, showed significant enhancement on AMCase expression. Such obtained results contribute to the basis of developing a promising therapeutic strategy for asthma by silencing AMCase expression. |
| Databáze: | OpenAIRE |
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