Metal-Free Decarboxylative Three-Component Coupling Reaction for the Synthesis of Propargylamines

Autor:	Kyungho Park, Sunwoo Lee, Yumi Heo
Rok vydání:	2013
Předmět:	chemistry.chemical_classification Chemistry Component (thermodynamics) Organic Chemistry Alkyne Biochemistry Coupling reaction Solvent chemistry.chemical_compound Metal free Yield (chemistry) Polymer chemistry Organic chemistry Physical and Theoretical Chemistry Paraformaldehyde Selectivity
Zdroj:	Organic Letters. 15:3322-3325
ISSN:	1523-7052 1523-7060
DOI:	10.1021/ol401358t
Popis:	A metal-free decarboxylative three-component coupling reaction was developed. When alkynyl carboxylic acids, paraformaldehyde, and amines were reacted in CH3CN at 65 °C for 3 h, the desired propargylamines were obtained in good yields. This coupling reaction also showed good yield in water solvent. This reaction showed higher selectivity toward alkynyl carboxylic acids than a terminal alkyne.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::502d498b9ee68a7bb824d8495d7545ca https://doi.org/10.1021/ol401358t Zobrazit plný text záznamu