Serotonergic agents that activate 5HT2A receptors prevent NMDA antagonist neurotoxicity
| Autor: | B.S Charity Kirby, B.S Jennifer Hanslick, M.D Nuri B Farber, M.D John W Olney, B.A Laurie McWilliams |
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| Rok vydání: | 1997 |
| Předmět: |
Agonist
medicine.drug_class Pharmacology Serotonergic Neuroprotection Receptors N-Methyl-D-Aspartate Rats Sprague-Dawley medicine Animals Phencyclidine 5-HT receptor Dose-Response Relationship Drug Amphetamines Psychotomimetic Rats Serotonin Receptor Agonists Dizocilpine Psychiatry and Mental health Ritanserin NMDA receptor Female Serotonin Antagonists Dizocilpine Maleate Psychology Neuroscience Excitatory Amino Acid Antagonists medicine.drug |
| Zdroj: | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 18(1) |
| ISSN: | 0893-133X |
| Popis: | Phencyclidine, ketamine, and other agents that block NMDA glutamate receptors trigger a schizophrenia-like psychosis in humans and induce pathomorphological changes in cerebrocortical neurons in rat brain. Accumulating evidence suggests that a complex network disturbance involving multiple transmitter receptor systems is responsible for the neuronal injury, and it is proposed that a similar network disturbance is responsible for the psychotomimetic effects of NMDA antagonists, and might also be involved in the pathophysiology of schizophrenia. In the present study we present evidence that serotonergic agents possessing 5HT2A agonist activity prevent NMDA antagonist neurotoxicity in rat brain. It is proposed that 5HT2A agonists may also prevent the psychotomimetic effects of NMDA antagonists. Among the 5HT2A agonists examined and found to be neuroprotective are LSD and related hallucinogens. The apparent contradiction in proposing that these agents might have antipsychotic properties is resolved by evidence linking their hallucinogenic activity to agonist action at 5HT2C receptors, whereas antipsychotic activity would be attributable to agonist action at 5HT2A receptors. |
| Databáze: | OpenAIRE |
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