Calcium-sensing receptor in the development and treatment of pulmonary hypertension
Autor: | Ming-Yuan Zhou, Ying-Jian Gu, Lin Cheng, Lei Chen, Yun Wang |
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Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Hypertension Pulmonary Myocytes Smooth Muscle Adamantane Pulmonary Artery Vascular Remodeling 03 medical and health sciences 0302 clinical medicine Cell Movement medicine.artery Quinoxalines Genetics medicine Extracellular Autophagy Animals Humans Receptor Molecular Biology Cell Proliferation business.industry Endothelial Cells Cell Differentiation General Medicine medicine.disease Calcium Channel Blockers Pulmonary hypertension 030104 developmental biology Gene Expression Regulation Apoptosis 030220 oncology & carcinogenesis Pulmonary artery Cancer research Calcium Calcium-sensing receptor business Receptors Calcium-Sensing Homeostasis Signal Transduction |
Zdroj: | Molecular biology reports. 48(1) |
ISSN: | 1573-4978 |
Popis: | Calcium-sensing receptor (CaSR) is widely involved in the cell proliferation, differentiation, migration, adhesion and apoptosis, which can affect the vascular remodeling in the humanbody. The main ligand of CaSR is extracellular Ca2+. CaSR has the physiological significance in Ca2+ homeostasis. Pulmonary vascular remodeling is one of the main histopathological changes of pulmonary hypertension (PH). The abnormal proliferation of pulmonary artery smooth muscle cells (PASMCs) results in the pulmonary vascular remodeling. CaSR is an important regulator of [Ca2+]i. [Ca2+]i is the main cause of the excessive pulmonary vascular remodeling in patients with PH. In this review, it was conclued that the structure of CaSR was prone to explore the devolopment or the treatment of PH. It was found that the regulation of CaSR with some miRNA could inhibit the proliferation of PASMCs, and that CaSR could affect the occurrence of autophagy in PH. Therefore, CaSR would become a new therapeutic target to PH. |
Databáze: | OpenAIRE |
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