[Associations between TGF-β1 G/A and TNF-α 308 G/A gene polymorphisms with airway resistance in chronic obstructive pulmonary disease]
| Autor: | Sarınç Ulaşlı S, Öner Eyüboğlu F, Ataç B, Gaye Ulubay, Melek K, Verdi H |
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| Rok vydání: | 2013 |
| Předmět: |
Pulmonary and Respiratory Medicine
Male medicine.medical_specialty Turkish population Genotype Turkey Critical Care and Intensive Care Medicine Gastroenterology Polymorphism Single Nucleotide Pulmonary function testing Pathogenesis Transforming Growth Factor beta1 Pulmonary Disease Chronic Obstructive Airway resistance Gene Frequency Internal medicine Medicine Plethysmograph Humans Genetic Association Studies Aged COPD Analysis of Variance business.industry Tumor Necrosis Factor-alpha Airway Resistance Middle Aged medicine.disease respiratory tract diseases Surgery Tumor necrosis factor alpha Female business |
| Zdroj: | Tuberkuloz ve toraks. 61(1) |
| ISSN: | 0494-1373 |
| Popis: | Chronic obstructive pulmonary disease (COPD) is an important morbidity and mortality cause all over the world. Although specific gene region has not been defined in the pathogenesis of COPD, cytokine gene polymorphisms like tumor necrosis factor-alfa (TNF-α) and transforming growth factor-beta1 (TGF-β1) may contribute to the development of COPD. The aim of the present study was to evaluate the associations between airway resistance with TGF-β1 G/A and TNF-α 308 G/A gene polymorphisms in COPD patients.264 subjects were included to the study (Group 1; 75 COPD patients, Group 2; 139 subjects with at least 10 packet year smoking history without airflow obstruction, Group 3; 50 healthy subjects). Pulmonary function tests and body plethysmography to measure airway resistance were performed to the subjects. TGF-β1 800 G/A and TNF-α 308 G/A gene polymorphisms were evaluated. Chi-square, Anova and correlation analysis were used for statistical analysis.There were significant difference among COPD stages in terms of TNF-α 308 G/A polymorphism (p0.05). Thirteen (23.6%) stage 1 COPD patients had TNF-α 308 G/A polymorphism and the other did not have. We did not find statistically significant difference among COPD stages in terms of TGF-β1 800 G/A polymorphism (p0.05). TNF-α and TGF-β1 genotypes and TNF-a 308 G/A and TGF-β1 800 G/A polymorphisms were not different among study groups. Moreover, no significant differences betweeen subjects with and without increased airway resistance in terms of TNF-α 308 G/A and TGF-β1 800 G/A polymorphisms were present.These results can suggest the lack of association between TNF-α 308 G/A and TGF-β1 800 G/A gene polymorphisms with COPD development and airway resistance in Turkish population. |
| Databáze: | OpenAIRE |
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